Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization

Protein ubiquitination is important for cell signaling, DNA repair, and proteasomal degradation, and it is not surprising that alterations in ubiquitination occur frequently in cancer. Ubiquitin-conjugating enzymes (E2) mediate ubiquitination by selective interactions with ubiquitin-activating (E1)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sanders, Matthew A., Brahemi, Ghali, Nangia-Makker, Pratima, Balan, Vitaly, Morelli, Matteo, Kothayer, Hend, Westwell, Andrew D., Shekhar, Malathy P.V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840907/
https://ncbi.nlm.nih.gov/pubmed/23339190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0793
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