Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs

Platinum drug-induced cross-link repair requires the concerted activities of translesion synthesis (TLS), Fanconi anemia (FA), and homologous recombination repair pathways. The E2 ubiquitin-conjugating enzyme RAD6 is essential for TLS. Here, we show that RAD6 plays a universal role in platinum-based...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sanders, Matthew A., Haynes, Brittany, Nangia-Makker, Pratima, Polin, Lisa A., Shekhar, Malathy P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481549/
https://ncbi.nlm.nih.gov/pubmed/28490629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792192
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