Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

Fouling of chromatographic resins over their operational lifetimes can be a significant problem for commercial bioseparations. In this article, scanning electron microscopy (SEM), batch uptake experiments, confocal laser scanning microscopy (CLSM) and small-scale column studies were applied to chara...

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Autores principales: Close, Edward J, Salm, Jeffrey R, Iskra, Timothy, Sørensen, Eva, Bracewell, Daniel G
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840701/
https://ncbi.nlm.nih.gov/pubmed/23483524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.24898
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