Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization

The ligand-gated channels transient receptor potential vanilloid 1 (TRPV1) and P2X3 have been reported to facilitate colorectal afferent neuron sensitization, thus contributing to organ hypersensitivity and pain. In the present study, we hypothesized that TRPV1 and P2X3 cooperate to modulate colorec...

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Autores principales: Kiyatkin, Michael E., Feng, Bin, Schwartz, Erica S., Gebhart, G. F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
Materias:
Neuroregulation and Motility
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840237/
https://ncbi.nlm.nih.gov/pubmed/23989007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00180.2013
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