Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization

The ligand-gated channels transient receptor potential vanilloid 1 (TRPV1) and P2X3 have been reported to facilitate colorectal afferent neuron sensitization, thus contributing to organ hypersensitivity and pain. In the present study, we hypothesized that TRPV1 and P2X3 cooperate to modulate colorec...

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Bibliografiska uppgifter
Huvudupphovsmän: Kiyatkin, Michael E., Feng, Bin, Schwartz, Erica S., Gebhart, G. F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2013
Ämnen:
Neuroregulation and Motility
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840237/
https://ncbi.nlm.nih.gov/pubmed/23989007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00180.2013
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