Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization

The ligand-gated channels transient receptor potential vanilloid 1 (TRPV1) and P2X3 have been reported to facilitate colorectal afferent neuron sensitization, thus contributing to organ hypersensitivity and pain. In the present study, we hypothesized that TRPV1 and P2X3 cooperate to modulate colorec...

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Autors principals: Kiyatkin, Michael E., Feng, Bin, Schwartz, Erica S., Gebhart, G. F.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
Matèries:
Neuroregulation and Motility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840237/
https://ncbi.nlm.nih.gov/pubmed/23989007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00180.2013
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