Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency

Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling p...

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Bibliographic Details
Main Authors: Yao, Yucheng, Yao, Jiayi, Radparvar, Melina, Blazquez-Medela, Ana M., Guihard, Pierre J., Jumabay, Medet, Boström, Kristina I.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839731/
https://ncbi.nlm.nih.gov/pubmed/24191040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310905110
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