The Angiogenic Factor Secretoneurin Induces Coronary Angiogenesis in a Model of Myocardial Infarction by Stimulation of VEGF Signaling in Endothelial Cells

BACKGROUND: Secretoneurin is a neuropeptide located in nerve fibers along blood vessels, is up-regulated by hypoxia and induces angiogenesis. We tested the hypothesis that secretoneurin gene therapy exerts beneficial effects in a rat model of myocardial infarction and evaluated the mechanism of acti...

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Autori principali: Albrecht-Schgoer, Karin, Schgoer, Wilfried, Holfeld, Johannes, Theurl, Markus, Wiedemann, Dominik, Steger, Christina, Gupta, Rajesh, Semsroth, Severin, Fischer-Colbrie, Reiner, Beer, Arno G.E., Stanzl, Ursula, Huber, Eva, Misener, Sol, Dejaco, Daniel, Kishore, Raj, Pachinger, Otmar, Grimm, Michael, Bonaros, Nikolaos, Kirchmair, Rudolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839617/
https://ncbi.nlm.nih.gov/pubmed/23081990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.076950
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