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Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling

Intracellular signaling is mediated by reversible posttranslational modifications (PTMs) that include phosphorylation, ubiquitination, and acetylation, among others. In response to extracellular stimuli such as growth factors, receptor tyrosine kinases (RTKs) typically dimerize and initiate signalin...

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Detalhes bibliográficos
Main Authors: Wagner, Melany J., Stacey, Melissa M., Liu, Bernard A., Pawson, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839611/
https://ncbi.nlm.nih.gov/pubmed/24296166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a008987
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