Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR–CML cell lines?

The hallmark of CML (chronic myeloid leukaemia) is the BCR (breakpoint cluster region)–ABL fusion gene. CML evolves through three phases, based on both clinical and pathological features: a chronic phase, an accelerated phase and blast crisis. TKI (tyrosine kinase inhibitors) are the treatment modal...

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Bibliographic Details
Main Authors: Rumjanek, Vivian M., Vidal, Raphael S., Maia, Raquel C.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2013
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839595/
https://ncbi.nlm.nih.gov/pubmed/24070327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20130067
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