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The thyroid cancer PAX8-PPARG Fusion Protein activates Wnt/TCF responsive cells that have a transformed phenotype

A chromosomal translocation results in the production of a PAX8-PPARG Fusion Protein (PPFP) in ~35% of follicular thyroid carcinomas. To examine the role of PPFP in thyroid oncogenesis, the fusion protein was stably expressed in the non-transformed rat thyroid cell line PCCL3. PPFP conferred on PCCL...

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Bibliografiska uppgifter
Huvudupphovsmän: Vu-Phan, Dang, Grachtchouk, Vladimir, Yu, Jingcheng, Colby, Lesley A., Wicha, Max S., Koenig, Ronald J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839064/
https://ncbi.nlm.nih.gov/pubmed/24025583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-13-0058
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