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Subtle changes to polymer structure and degradation mechanism enable highly effective nanoparticles for siRNA and DNA delivery to human brain cancer

Polymeric materials can be used to deliver nucleic acids such as DNA plasmids and siRNA, but often have low efficacy in human cells. To improve gene delivery, we synthesized an array of over 70 hydrolytically degradable and bioreducible poly(beta-amino ester)s and evaluated properties of over 200 na...

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Bibliografische gegevens
Hoofdauteurs: Tzeng, Stephany Y., Green, Jordan J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838886/
https://ncbi.nlm.nih.gov/pubmed/23184674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201200257
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