PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

In the liver, insulin suppresses hepatic gluconeogenesis by activating Akt, which inactivates the key gluconeogenic transcription factor FoxO1 (Forkhead Box O1). Recent studies have implicated hyperactivity of the Akt phosphatase Protein Phosphatase 2A (PP2A) and impaired Akt signaling as a molecula...

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Hlavní autoři: Galbo, Thomas, Perry, Rachel J., Nishimura, Erica, Samuel, Varman T., Quistorff, Bjørn, Shulman, Gerald I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838779/
https://ncbi.nlm.nih.gov/pubmed/24150286
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