PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

In the liver, insulin suppresses hepatic gluconeogenesis by activating Akt, which inactivates the key gluconeogenic transcription factor FoxO1 (Forkhead Box O1). Recent studies have implicated hyperactivity of the Akt phosphatase Protein Phosphatase 2A (PP2A) and impaired Akt signaling as a molecula...

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Autori principali: Galbo, Thomas, Perry, Rachel J., Nishimura, Erica, Samuel, Varman T., Quistorff, Bjørn, Shulman, Gerald I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2013
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838779/
https://ncbi.nlm.nih.gov/pubmed/24150286
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