PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

In the liver, insulin suppresses hepatic gluconeogenesis by activating Akt, which inactivates the key gluconeogenic transcription factor FoxO1 (Forkhead Box O1). Recent studies have implicated hyperactivity of the Akt phosphatase Protein Phosphatase 2A (PP2A) and impaired Akt signaling as a molecula...

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Bibliografske podrobnosti
Main Authors: Galbo, Thomas, Perry, Rachel J., Nishimura, Erica, Samuel, Varman T., Quistorff, Bjørn, Shulman, Gerald I.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2013
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838779/
https://ncbi.nlm.nih.gov/pubmed/24150286
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