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In vivo investigation of cardiac metabolism in the rat using MRS of hyperpolarized [1-(13)C] and [2-(13)C]pyruvate

Hyperpolarized (13)C MRS allows the in vivo assessment of pyruvate dehydrogenase complex (PDC) flux, which converts pyruvate to acetyl-coenzyme A (acetyl-CoA). [1-(13)C]pyruvate has been used to measure changes in cardiac PDC flux, with demonstrated increase in (13)C-bicarbonate production after dic...

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Autori principali: Josan, Sonal, Park, Jae Mo, Hurd, Ralph, Yen, Yi-Fen, Pfefferbaum, Adolf, Spielman, Daniel, Mayer, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838505/
https://ncbi.nlm.nih.gov/pubmed/23904148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3003
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