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A distal mutation perturbs dynamic amino acid networks in dihydrofolate reductase
Correlated networks of amino acids have been proposed to play a fundamental role in allostery and enzyme catalysis. These networks of amino acids can be traced from surface-exposed residues all the way into the active site, and disruption of these networks can decrease enzyme activity. Substitution...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838469/ https://ncbi.nlm.nih.gov/pubmed/23758161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400563c |
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