A Chimeric Dengue Virus Vaccine using Japanese Encephalitis Virus Vaccine Strain SA14-14-2 as Backbone Is Immunogenic and Protective against Either Parental Virus in Mice and Nonhuman Primates

The development of a safe and efficient dengue vaccine represents a global challenge in public health. Chimeric dengue viruses (DENV) based on an attenuated flavivirus have been well developed as vaccine candidates by using reverse genetics. In this study, based on the full-length infectious cDNA cl...

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Detalhes bibliográficos
Main Authors: Li, Xiao-Feng, Deng, Yong-Qiang, Yang, Hui-Qiang, Zhao, Hui, Jiang, Tao, Yu, Xue-Dong, Li, Shi-Hua, Ye, Qing, Zhu, Shun-Ya, Wang, Hong-Jiang, Zhang, Yu, Ma, Jie, Yu, Yong-Xin, Liu, Zhong-Yu, Li, Yu-Hua, Qin, E-De, Shi, Pei-Yong, Qin, Cheng-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838253/
https://ncbi.nlm.nih.gov/pubmed/24109223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00931-13
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