Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Li, Xiao-Feng, Dong, Hao-Long, Wang, Hong-Jiang, Huang, Xing-Yao, Qiu, Ye-Feng, Ji, Xue, Ye, Qing, Li, Chunfeng, Liu, Yang, Deng, Yong-Qiang, Jiang, Tao, Cheng, Gong, Zhang, Fu-Chun, Davidson, Andrew D., Song, Ya-Jun, Shi, Pei-Yong, Qin, Cheng-Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813210/
https://ncbi.nlm.nih.gov/pubmed/29445153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02975-w
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