Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

p53 is a multifunctional tumor suppressor protein involved in the negative control of cell growth. Mutations in p53 cause alterations in cellular phenotype, including immortalization, neoplastic transformation, and resistance to DNA-damaging drugs. To help dissect distinct functions of p53, a set of...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Ossovskaya, V S, Mazo, I A, Chernov, M V, Chernova, O B, Strezoska, Z, Kondratov, R, Stark, G R, Chumakov, P M, Gudkov, A V
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10309
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