Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.

p53 is a multifunctional tumor suppressor protein involved in the negative control of cell growth. Mutations in p53 cause alterations in cellular phenotype, including immortalization, neoplastic transformation, and resistance to DNA-damaging drugs. To help dissect distinct functions of p53, a set of...

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Detalhes bibliográficos
Main Authors: Ossovskaya, V S, Mazo, I A, Chernov, M V, Chernova, O B, Strezoska, Z, Kondratov, R, Stark, G R, Chumakov, P M, Gudkov, A V
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC38380/
https://ncbi.nlm.nih.gov/pubmed/8816796
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