Increasing the Potency of an Alhydrogel-Formulated Anthrax Vaccine by Minimizing Antigen-Adjuvant Interactions

Aluminum salts are the most widely used vaccine adjuvants, and phosphate is known to modulate antigen-adjuvant interactions. Here we report an unexpected role for phosphate buffer in an anthrax vaccine (SparVax) containing recombinant protective antigen (rPA) and aluminum oxyhydroxide (AlOH) adjuvan...

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Autori principali: Watkinson, Allan, Soliakov, Andrei, Ganesan, Ashok, Hirst, Karie, LeButt, Chris, Fleetwood, Kelly, Fusco, Peter C., Fuerst, Thomas R., Lakey, Jeremy H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837781/
https://ncbi.nlm.nih.gov/pubmed/23986317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00320-13
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