Schwann Cell LRP1 Regulates Remak Bundle Ultrastructure and Axonal Interactions to Prevent Neuropathic Pain

Trophic support and myelination of axons by Schwann cells in the PNS are essential for normal nerve function. Herein, we show that deletion of the LDL receptor-related protein-1 (LRP1) gene in Schwann cells (scLRP1(−/−)) induces abnormalities in axon myelination and in ensheathment of axons by nonmy...

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Autors principals: Orita, Sumihisa, Henry, Kenneth, Mantuano, Elisabetta, Yamauchi, Kazuyo, De Corato, Alice, Ishikawa, Tetsuhiro, Feltri, M. Laura, Wrabetz, Lawrence, Gaultier, Alban, Pollack, Melanie, Ellisman, Mark, Takahashi, Kazuhisa, Gonias, Steven L., Campana, W. Marie
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837698/
https://ncbi.nlm.nih.gov/pubmed/23536074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3342-12.2013
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