Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs). The Ku protein has double-stranded DNA end-binding activity that serves to recruit the complex to DNA ends. Despite having serine/threonine protein kinase activity, DNA-PKcs falls...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Blunt, T, Gell, D, Fox, M, Taccioli, G E, Lehmann, A R, Jackson, S P, Jeggo, P A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8816792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.19.10285
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