(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

Of a series of five newly synthesized 2'-deoxyuridine derivatives, including 5-vinyl-dUrd, 5-ethynyl-dUrd, 5-(1-chlorovinyl)-dUrd, (E)-5-(2-bromovinyl)-dUrd, and (E)-5-(2-iodovinyl)-dUrd, the last two compounds were found to exert a marked inhibitory effect on the replication of herpes simplex...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: De Clercq, E, Descamps, J, De Somer, P, Barr, P J, Jones, A S, Walker, R T
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1979
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383727/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/223163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.6.2947
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