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On-Line Electrochemical Reduction of Disulfide Bonds: Improved FTICR-CID and -ETD Coverage of Oxytocin and Hepcidin

Particularly in the field of middle- and top-down peptide and protein analysis, disulfide bridges can severely hinder fragmentation and thus impede sequence analysis (coverage). Here we present an on-line/electrochemistry/ESI-FTICR-MS approach, which was applied to the analysis of the primary struct...

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Hlavní autoři: Nicolardi, Simone, Giera, Martin, Kooijman, Pieter, Kraj, Agnieszka, Chervet, Jean-Pierre, Deelder, André M., van der Burgt, Yuri E. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837188/
https://ncbi.nlm.nih.gov/pubmed/24018861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-013-0725-7
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