Leptin Regulates K(ATP) Channel Trafficking in Pancreatic β-Cells by a Signaling Mechanism Involving AMP-activated Protein Kinase (AMPK) and cAMP-dependent Protein Kinase (PKA)

Pancreatic β-cells secrete insulin in response to metabolic and hormonal signals to maintain glucose homeostasis. Insulin secretion is under the control of ATP-sensitive potassium (K(ATP)) channels that play key roles in setting β-cell membrane potential. Leptin, a hormone secreted by adipocytes, in...

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Main Authors: Chen, Pei-Chun, Kryukova, Yelena N., Shyng, Show-Ling
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837151/
https://ncbi.nlm.nih.gov/pubmed/24100028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516880
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