Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets

Apolipoproteins (apo) C-I and C-III are known to inhibit lipoprotein lipase (LPL) activity, but the molecular mechanisms for this remain obscure. We present evidence that either apoC-I or apoC-III, when bound to triglyceride-rich lipoproteins, prevent binding of LPL to the lipid/water interface. Thi...

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Bibliografiska uppgifter
Huvudupphovsmän: Larsson, Mikael, Vorrsjö, Evelina, Talmud, Philippa, Lookene, Aivar, Olivecrona, Gunilla
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Enzymology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837139/
https://ncbi.nlm.nih.gov/pubmed/24121499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.495366
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