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Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition
Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding. To probe this, we used oil-drop tensiometry to characterize binding of six apoC-III...
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| Publicado no: | J Lipid Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5408602/ https://ncbi.nlm.nih.gov/pubmed/28159869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M071126 |
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