Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)

GPIHBP1 is an endothelial membrane protein that transports lipoprotein lipase (LPL) from the subendothelial space to the luminal side of the capillary endothelium. Here, we provide evidence that two regions of GPIHBP1, the acidic N-terminal domain and the central Ly6 domain, interact with LPL as two...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Reimund, Mart, Larsson, Mikael, Kovrov, Oleg, Kasvandik, Sergo, Olivecrona, Gunilla, Lookene, Aivar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Lipids
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447966/
https://ncbi.nlm.nih.gov/pubmed/25873395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634626
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