Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)

GPIHBP1 is an endothelial membrane protein that transports lipoprotein lipase (LPL) from the subendothelial space to the luminal side of the capillary endothelium. Here, we provide evidence that two regions of GPIHBP1, the acidic N-terminal domain and the central Ly6 domain, interact with LPL as two...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Reimund, Mart, Larsson, Mikael, Kovrov, Oleg, Kasvandik, Sergo, Olivecrona, Gunilla, Lookene, Aivar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447966/
https://ncbi.nlm.nih.gov/pubmed/25873395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.634626
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