Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways

Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of MAPKs. Several drugs with immune-suppressive properties modulate MKP-1 expression as part of their mechanism of action. We investigated the effec...

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Main Authors: Rastogi, Ruchi, Jiang, Zhongliang, Ahmad, Nisar, Rosati, Rita, Liu, Yusen, Beuret, Laurent, Monks, Robert, Charron, Jean, Birnbaum, Morris J., Samavati, Lobelia
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837136/
https://ncbi.nlm.nih.gov/pubmed/24126911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492702
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