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Understanding the Connection between Epigenetic DNA Methylation and Nucleosome Positioning from Computer Simulations

Cytosine methylation is one of the most important epigenetic marks that regulate the process of gene expression. Here, we have examined the effect of epigenetic DNA methylation on nucleosomal stability using molecular dynamics simulations and elastic deformation models. We found that methylation of...

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Autori principali: Portella, Guillem, Battistini, Federica, Orozco, Modesto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836855/
https://ncbi.nlm.nih.gov/pubmed/24278005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003354
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