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Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: a multiscale computational study

Histone tails and their epigenetic modifications play crucial roles in gene expression regulation by altering the architecture of chromatin. However, the structural mechanisms by which histone tails influence the interconversion between active and inactive chromatin remain unknown. Given the technic...

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Pubblicato in:J Am Chem Soc
Autori principali: Collepardo-Guevara, Rosana, Portella, Guillem, Vendruscolo, Michele, Frenkel, Daan, Schlick, Tamar, Orozco, Modesto
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251407/
https://ncbi.nlm.nih.gov/pubmed/26192632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04086
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