Complete Atrial-Specific Knockout of Sodium-Calcium Exchange Eliminates Sinoatrial Node Pacemaker Activity

The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. The leading candidates are diastolic depolarization by “funny” current (I(f)) through HCN4 channels (the “Membrane Clock“ hypothesis), depolarization by cardiac Na-Ca exchange (NCX1) in response to intracellular Ca...

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Main Authors: Groenke, Sabine, Larson, Eric D., Alber, Sarah, Zhang, Rui, Lamp, Scott T., Ren, Xiaoyan, Nakano, Haruko, Jordan, Maria C., Karagueuzian, Hrayr S., Roos, Kenneth P., Nakano, Atsushi, Proenza, Catherine, Philipson, Kenneth D., Goldhaber, Joshua I.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836769/
https://ncbi.nlm.nih.gov/pubmed/24278453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081633
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