Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer

Recent genome-wide association studies (GWASs) have identified common variants at 16 autosomal regions influencing the risk of developing colorectal cancer (CRC). To decipher the genetic basis of the association signals at these loci, we performed a meta-analysis of data from five GWASs, totalling 5...

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Main Authors: Whiffin, Nicola, Dobbins, Sara E., Hosking, Fay J., Palles, Claire, Tenesa, Albert, Wang, Yufei, Farrington, Susan M., Jones, Angela M., Broderick, Peter, Campbell, Harry, Newcomb, Polly A., Casey, Graham, Conti, David V., Schumacher, Fred, Gallinger, Steve, Lindor, Noralane M., Hopper, John, Jenkins, Mark, Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Association Studies Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836483/
https://ncbi.nlm.nih.gov/pubmed/23904454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt357
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