Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes

We have previously identified several colorectal cancer (CRC)-associated polymorphisms using genome-wide association (GWA) analysis. We sought to fine-map the location of the functional variants for three of these regions at 8q23.3 (EIF3H), 16q22.1 (CDH1/CDH3) and 19q13.11 (RHPN2). We genotyped two...

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Main Authors: Carvajal-Carmona, Luis G., Cazier, Jean-Baptiste, Jones, Angela M., Howarth, Kimberley, Broderick, Peter, Pittman, Alan, Dobbins, Sara, Tenesa, Albert, Farrington, Susan, Prendergast, James, Theodoratou, Evi, Barnetson, Rebecca, Conti, David, Newcomb, Polly, Hopper, John L., Jenkins, Mark A., Gallinger, Steven, Duggan, David J., Campbell, Harry, Kerr, David, Casey, Graham, Houlston, Richard, Dunlop, Malcolm, Tomlinson, Ian
格式: Artigo
語言:Inglês
出版: Oxford University Press 2011
主題:
Association Studies Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118761/
https://ncbi.nlm.nih.gov/pubmed/21531788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr190
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