PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses

An enzymatically activatable prodrug of doxorubicin was covalently coupled, using click-chemistry, to the hydrophobic core of poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl)-methacrylamide-lactate] micelles. The release and cytotoxic activity of the prodrug was evaluated in vitro in A549 non-small-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ruiz-Hernández, Eduardo, Hess, Michael, Melen, Gustavo J., Theek, Benjamin, Talelli, Marina, Shi, Yang, Ozbakir, Burcin, Teunissen, Erik A., Ramírez, Manuel, Moeckel, Diana, Kiessling, Fabian, Storm, Gert, Scheeren, Hans W., Hennink, Wim E., Szalay, Aladar A., Stritzker, Jochen, Lammers, Twan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836408/
https://ncbi.nlm.nih.gov/pubmed/24518685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3PY01097J
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