PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses

An enzymatically activatable prodrug of doxorubicin was covalently coupled, using click-chemistry, to the hydrophobic core of poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl)-methacrylamide-lactate] micelles. The release and cytotoxic activity of the prodrug was evaluated in vitro in A549 non-small-...

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Detalhes bibliográficos
Main Authors: Ruiz-Hernández, Eduardo, Hess, Michael, Melen, Gustavo J., Theek, Benjamin, Talelli, Marina, Shi, Yang, Ozbakir, Burcin, Teunissen, Erik A., Ramírez, Manuel, Moeckel, Diana, Kiessling, Fabian, Storm, Gert, Scheeren, Hans W., Hennink, Wim E., Szalay, Aladar A., Stritzker, Jochen, Lammers, Twan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836408/
https://ncbi.nlm.nih.gov/pubmed/24518685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3PY01097J
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