PEG-pHPMAm-based polymeric micelles loaded with doxorubicin-prodrugs in combination antitumor therapy with oncolytic vaccinia viruses

An enzymatically activatable prodrug of doxorubicin was covalently coupled, using click-chemistry, to the hydrophobic core of poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl)-methacrylamide-lactate] micelles. The release and cytotoxic activity of the prodrug was evaluated in vitro in A549 non-small-...

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Главные авторы: Ruiz-Hernández, Eduardo, Hess, Michael, Melen, Gustavo J., Theek, Benjamin, Talelli, Marina, Shi, Yang, Ozbakir, Burcin, Teunissen, Erik A., Ramírez, Manuel, Moeckel, Diana, Kiessling, Fabian, Storm, Gert, Scheeren, Hans W., Hennink, Wim E., Szalay, Aladar A., Stritzker, Jochen, Lammers, Twan
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836408/
https://ncbi.nlm.nih.gov/pubmed/24518685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3PY01097J
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