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The Spindle Assembly Checkpoint works like a rheostat not a toggle-switch
The Spindle Assembly Checkpoint (SAC) is essential in mammalian mitosis to ensure the equal segregation of sister chromatids(1, 2). The SAC generates a Mitotic Checkpoint Complex (MCC) to prevent the Anaphase Promoting Complex/Cyclosome (APC/C) from targeting key mitotic regulators for destruction u...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836401/ https://ncbi.nlm.nih.gov/pubmed/24096242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2855 |
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