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S-Adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin

The human lymphoblast line WI-L2 is subject to growth inhibition by a combination of the adenosine deaminase (ADA; adenosine aminohydrolase, EC 3.5.4.4.) inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) and adenosine. Although adenosine-induced pyrimidine starvation appears to contribute to thi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kredich, Nicholas M., Hershfield, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1979
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383620/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/221926/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.5.2450
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