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Biochemical basis for differential deoxyadenosine toxicity to T and B lymphoblasts: role for 5'-nucleotidase.

Deoxyadenosine metabolism was investigated in cultured human cells to elucidate the biochemical basis for the sensitivity of T lymphoblasts and the resistance of B lymphoblasts to deoxyadenosine toxicity. T lymphoblasts have a 20-to 45-fold greater capacity to synthesize deoxyadenosine nucleotides t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wortmann, R L, Mitchell, B S, Edwards, N L, Fox, I H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383616/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/221924/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.5.2434
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