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Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides
Pharmacological modulation of p53 activity is an attractive therapeutic strategy in cancers with wild-type p53. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2, a key negative regulator of p53 and blocks its activity. We have described resistance mutations in H...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3835680/ https://ncbi.nlm.nih.gov/pubmed/24278380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081068 |
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