JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation

The cJun NH(2)-terminal kinase (JNK) signaling pathway contributes to inflammation and plays a key role in the metabolic response to obesity, including insulin resistance. Macrophages are implicated in this process. To test the role of JNK, we established mice with selective JNK-deficiency in macrop...

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Bibliographic Details
Main Authors: Han, Myoung Sook, Jung, Dae Young, Morel, Caroline, Lakhani, Saquib A., Kim, Jason K., Flavell, Richard A., Davis, Roger J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835653/
https://ncbi.nlm.nih.gov/pubmed/23223452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227568
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