An Endogenously Produced Fragment of Cardiac Myosin Binding Protein C is Pathogenic and Can Lead to Heart Failure

RATIONALE: A stable 40 kD fragment is produced from cardiac myosin binding protein-C (cMyBP-C) when the heart is stressed, using a stimulus such as ischemia reperfusion injury. Elevated levels of the fragment can be detected in both the diseased mouse and human heart but its ability to interfere wit...

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Bibliographic Details
Main Authors: Razzaque, Abdur, Gupta, Manish, Osinska, Hanna, Gulick, James, Blaxall, Burns C., Robbins, Jeffrey
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835189/
https://ncbi.nlm.nih.gov/pubmed/23852539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301225
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