Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans

BACKGROUND & AIMS: Roux-en-Y gastric bypass (RYGB) improves glucose homeostasis independently of changes in body weight by unknown mechanisms. Melanocortin-4 receptors (MC4R) have weight-independent effects on glucose homeostasis, via autonomic neurons, and might also contribute to weight loss a...

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Main Authors: Zechner, Juliet F., Mirshahi, Uyenlinh L., Satapati, Santhosh, Berglund, Eric D., Rossi, Jari, Scott, Michael M., Still, Christopher D., Gerhard, Glenn S., Burgess, Shawn C., Mirshahi, Tooraj, Aguirre, Vincent
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835150/
https://ncbi.nlm.nih.gov/pubmed/23159449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.11.022
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