The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

Oxidation of retinol via retinaldehyde results in the formation of the essential morphogen all-trans-retinoic acid (ATRA). Previous studies have identified critical roles in the regulation of embryonic ATRA levels for retinol, retinaldehyde, and ATRA-oxidizing enzymes; however, the contribution of r...

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Библиографические подробности
Главные авторы: Billings, Sara E., Pierzchalski, Keely, Butler Tjaden, Naomi E., Pang, Xiao-Yan, Trainor, Paul A., Kane, Maureen A., Moise, Alexander R.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2013
Предметы:
Research Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834788/
https://ncbi.nlm.nih.gov/pubmed/24005908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-227967
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