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The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

Oxidation of retinol via retinaldehyde results in the formation of the essential morphogen all-trans-retinoic acid (ATRA). Previous studies have identified critical roles in the regulation of embryonic ATRA levels for retinol, retinaldehyde, and ATRA-oxidizing enzymes; however, the contribution of r...

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Detalhes bibliográficos
Main Authors: Billings, Sara E., Pierzchalski, Keely, Butler Tjaden, Naomi E., Pang, Xiao-Yan, Trainor, Paul A., Kane, Maureen A., Moise, Alexander R.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834788/
https://ncbi.nlm.nih.gov/pubmed/24005908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-227967
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