The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development

Oxidation of retinol via retinaldehyde results in the formation of the essential morphogen all-trans-retinoic acid (ATRA). Previous studies have identified critical roles in the regulation of embryonic ATRA levels for retinol, retinaldehyde, and ATRA-oxidizing enzymes; however, the contribution of r...

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Hlavní autoři: Billings, Sara E., Pierzchalski, Keely, Butler Tjaden, Naomi E., Pang, Xiao-Yan, Trainor, Paul A., Kane, Maureen A., Moise, Alexander R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2013
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834788/
https://ncbi.nlm.nih.gov/pubmed/24005908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-227967
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