Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

We investigated how complement activation promotes tissue injury and organ dysfunction during acute inflammation. Three models of acute lung injury (ALI) induced by LPS, IgG immune complexes, or C5a were used in C57BL/6 mice, all models requiring availability of both C5a receptors (C5aR and C5L2) fo...

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Bibliographic Details
Main Authors: Bosmann, Markus, Grailer, Jamison J., Ruemmler, Robert, Russkamp, Norman F., Zetoune, Firas S., Sarma, J. Vidya, Standiford, Theodore J., Ward, Peter A.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834784/
https://ncbi.nlm.nih.gov/pubmed/23982144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-236380
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