De novo generation of infectious prions with bacterially expressed recombinant prion protein

The prion hypothesis is strongly supported by the fact that prion infectivity and the pathogenic conformer of prion protein (PrP) are simultaneously propagated in vitro by the serial protein misfolding cyclic amplification (sPMCA). However, due to sPMCA's enormous amplification power, whether a...

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Autors principals: Zhang, Zhihong, Zhang, Yi, Wang, Fei, Wang, Xinhe, Xu, Yuanyuan, Yang, Huaiyi, Yu, Guohua, Yuan, Chonggang, Ma, Jiyan
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2013
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834773/
https://ncbi.nlm.nih.gov/pubmed/23970796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-233965
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