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High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy()

Three-dimensional (3D) structure determination by single particle electron cryomicroscopy (cryoEM) involves the calculation of an initial 3D model, followed by extensive iterative improvement of the orientation determination of the individual particle images and the resulting 3D map. Because there i...

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Main Authors: Chen, Shaoxia, McMullan, Greg, Faruqi, Abdul R., Murshudov, Garib N., Short, Judith M., Scheres, Sjors H.W., Henderson, Richard
格式: Artigo
語言:Inglês
出版: Elsevier 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834153/
https://ncbi.nlm.nih.gov/pubmed/23872039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ultramic.2013.06.004
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