High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy()

Three-dimensional (3D) structure determination by single particle electron cryomicroscopy (cryoEM) involves the calculation of an initial 3D model, followed by extensive iterative improvement of the orientation determination of the individual particle images and the resulting 3D map. Because there i...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Shaoxia, McMullan, Greg, Faruqi, Abdul R., Murshudov, Garib N., Short, Judith M., Scheres, Sjors H.W., Henderson, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834153/
https://ncbi.nlm.nih.gov/pubmed/23872039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ultramic.2013.06.004
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