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A Novel Noncanonical Signaling Pathway for the µ-Opioid Receptor
The µ-opioid receptor (OPRM1) signals as a classic G protein–coupled receptor by activating heterotrimeric G(i)/G(o) proteins resulting in adenylyl cyclase (AC) inhibition. Such AC inhibition is desensitized after prolonged agonist treatment. However, after receptor desensitization, the intracellula...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834144/ https://ncbi.nlm.nih.gov/pubmed/24061856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.088278 |
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